FDA-Approved Trifluoromethyl Group-Containing Drugs: A Review of 20 Years

As people around the world regard 2020 as the year of COVID-19, the medical community considers this year to be the second-best year, shared with the year 1996, with respect to the number of drug molecules approved by the US Food and Drug Administration (FDA). Both years, 2020 and 1996, had a record of 53 new drug molecules approved by the FDA. In the year 2020, 53 new chemical entities and 13 biological medicines were approved, including 10 monoclonal antibodies, 2 antibody-drug conjugates, 3 peptides, and 2 oligonucleotides. Among them, most of the compounds were found to have fluorine or fluorine-containing functional groups exhibiting numerous pharmacological activities. Herein, we summarized the trifluoromethyl (TFM, -CF3)-group-containing FDA-approved drugs for the last 20 years. This article specially features and details the previous 20-year literature data, covering CF3-incorporated potential drug molecules, including their syntheses and uses for various diseases and disorders. The review covers the detailed chemistry of 19 FDA-approved drugs in the past 20 years, which contains the TFM group as one of the pharmacophores.

Assessment of COVID-19 Treatment Advised in Different Ethnic Populations.

A virus is an infectious agent that can only replicate within a host organism and can infect a variety of living organisms, including bacteria, plants, and animals. Viruses are so small that a microscope is necessary to visualize them, and they have a very simple structure. A coronavirus is a group of viruses that can cause diseases, for instance, the basic cold, severe acute respiratory syndrome (SARS), and the Middle East respiratory syndrome (MERS). The patients affected with the COVID-19 infection will encounter respiratory sickness and can recuperate without requiring normal therapy. Individuals with clinical issues like cardiovascular problems, diabetes, and respiratory illness will suffer from the ailment. COVID-19 disease spreads through aerosols or the nose when an infected individual hacks or sneezes. In 2019, a new disease, known as novel coronavirus disease 2019 (COVID-19), was discovered in China, and on March 11, 2020, it was declared a pandemic disease by the World Health Organization (WHO), spreading rapidly across 194 countries in Europe, North America, Asia, the Middle East, Latin America, and Africa. The best way to stop the spread of the transmission is to be instructed about COVID-19 and how it spreads. In this survey, we are endeavoring to focus on the drugs and vaccines that are used for the treatment and prevention of COVID-19.